Protease Activity: Meeting Its Theranostic Potential
نویسندگان
چکیده
منابع مشابه
Protease Activity: Meeting Its Theranostic Potential
This themed issue provides up-to-date review and research articles covering the theranostic applications in the combined fields of protease research, diagnostics and drug development.
متن کاملDengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target.
Flaviviral NS3 serine proteases require the NS2B cofactor region (cNS2B) to be active. Recent crystal structures of WNV (West Nile virus) protease in complex with inhibitors revealed that cNS2B participates in the formation of the protease active site. No crystal structures of ternary complexes are currently available for DENV (dengue virus) to validate the role of cNS2B in active site formatio...
متن کاملTheranostic Potential of Oncolytic Vaccinia Virus
Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinical development. However this also makes their pre-clinical and clinical study ...
متن کاملPhotodynamic therapy using a protease-mediated theranostic agent reduces cathepsin-B activity in mouse atheromata in vivo.
OBJECTIVE To investigate whether an intravenously injected cathepsin-B activatable theranostic agent (L-SR15) would be cleaved in and release a fluorescent agent (chlorin-e6) in mouse atheromata, allowing both the diagnostic visualization and therapeutic application of these fluorophores as photosensitizers during photodynamic therapy to attenuate plaque-destabilizing cathepsin-B activity by se...
متن کاملImmobilization of Alkaline Protease produced from Bacillus Licheniformis PTCC1331 on Calcium Alginate (Its effect on enzymatic activity)
Alkaline Protease enzyme produced from Bacillus Licheniformis PTCC1331 in optimum Condition(Temperature 37 ?C, 150 rpm, PH=10), is immobilized in different concentrations of Sodium Alginate using entrapment method, to increase its thermal resistance in detergents, and its activity is measured thereafter. Maximum enzymatic activity of 46 was obtained in 2%w/v Sodium alginate solution. Investiga...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2012
ISSN: 1838-7640
DOI: 10.7150/thno.4129